Small Heat Shock Protein

Preferred Label : Small Heat Shock Protein;

NCIt synonyms : Heat Shock Protein Family B; sHSP Family; sHsp; Small Heat Shock Protein Family; Heat Shock Protein Family B (Small); HSPB;

NCIt definition : A family of chaperone proteins with subunit molecular masses of 12-43 kDa. The members are characterized by the presence of a highly conserved stretch of 80-100 amino acids in their C-terminal domains called the alpha-crystallin domain (ACD). Class I small heat shock proteins (sHsps) are widely expressed and play a role in cell survival. Class II sHsps are expressed in tissue-specific patterns and may be involved in the differentiation, development and specific functionality for the tissues they are expressed in.;

PubMed : 25556000;

Details

Origin ID

C136829;

UMLS CUI

C1564779;

Automatic exact mappings (from CISMeF team)
- Heat-Shock proteins, small [MeSH concept]
- heat-shock proteins [MeSH Descriptor]
- heat-shock proteins, small [MeSH Descriptor]
Biochemical function of gene products
- Alpha-Crystallin B Chain [NCIt concept]
- Heat Shock Protein Beta-1 [NCIt concept]
- Heat Shock Protein Beta-8 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Heat-Shock proteins, small [MeSH concept]
- heat-shock proteins, small [MeSH Descriptor]
gene_product_has_biochemical_function
- Chaperone [NCIt concept]
- Stress-Induced Protein [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Protein Folding [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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