Prelamin-A/C - CISMeF

Preferred Label : Prelamin-A/C;

NCIt synonyms : Lamin-A/C Precursor; Renal Carcinoma Antigen NY-REN-32 Precursor; LMNA; Prelamin A; Prelamin A/C; Prelamin-A;

NCIt definition : Prelamin-A/C (664 aa, 74 kDa) is encoded by the human LMNA gene. This protein is involved in the framework required for the nuclear envelope and in chromatin interactions.;

NCIt note : UniProt considers prelamin-A the canonical sequence; prelamin-C (572 aa, 65 kDa) has a different amino acid sequence at residues 567-572 and is missing residues 573-664.; Prelamin-A/C must be farnesylated before it can be proteolytically processed by CAAX prenyl protease 1 homolog to remove 3 C-terminal and then must be methylated before it can be proteolytically processed to remove 15 C-terminal residues to yield lamin-A/C.;

Details

Origin ID

C96447;

UMLS CUI

C3272784;

Automatic exact mappings (from CISMeF team)
- Lamin a/C [OMIM gene]
- lamin A/C [ORDO Gene]
- prelamin A [MeSH concept]
- prelamin A [MeSH Supplementary Concept]
OMIM relation
- Lamin a/C [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Intermediate Filament Gene [NCIt concept]
- LMNA Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Intermediate Filament [NCIt concept]
- Nuclear Lamina [NCIt concept]
gene_product_has_biochemical_function
- Nuclear Matrix Protein [NCIt concept]
- Scaffolding Protein [NCIt concept]
gene_product_has_chemical_classification
- Lamin [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Aging [NCIt concept]
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
has_gene_product_element
- Lamin-A/C [NCIt concept]

Keyword's position in hierarchy(ies) :

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