" /> Prelamin-A/C - CISMeF





Preferred Label : Prelamin-A/C;

NCIt synonyms : Lamin-A/C Precursor; Renal Carcinoma Antigen NY-REN-32 Precursor; LMNA; Prelamin A; Prelamin A/C; Prelamin-A;

NCIt definition : Prelamin-A/C (664 aa, 74 kDa) is encoded by the human LMNA gene. This protein is involved in the framework required for the nuclear envelope and in chromatin interactions.;

NCIt note : UniProt considers prelamin-A the canonical sequence; prelamin-C (572 aa, 65 kDa) has a different amino acid sequence at residues 567-572 and is missing residues 573-664.; Prelamin-A/C must be farnesylated before it can be proteolytically processed by CAAX prenyl protease 1 homolog to remove 3 C-terminal and then must be methylated before it can be proteolytically processed to remove 15 C-terminal residues to yield lamin-A/C.;

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30/07/2025


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