Nuclear Lamina

Preferred Label : Nuclear Lamina;

NCIt definition : The nuclear lamina is a proteinaceous filamentous meshwork of lamin proteins interacting with integral proteins of the inner nuclear membrane, including emerin, and is thought to play a role in nuclear stability, chromatin structure, and gene expression. Lamins are highly conserved in evolution and members of the intermediate filament protein family. Mammalian lamins are classified into two major types, A and B, with two subspecies of each: lamins A and C for the A type and B1 and B2 for the B type. Lamins A and C arise from one gene by alternative splicing. Pre-lamin A contains a carboxyl CAAX box that can be modified by farnesylation. During mitosis, the lamina meshwork is reversibly disassembled in parallel with phosphorylation of the lamins.;

Details

Origin ID

C13809;

UMLS CUI

C1136039;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Nuclear Membrane [NCIt concept]
Associated anatomy of gene products
- Delta(14)-Sterol Reductase LBR [NCIt concept]
- Lamin [NCIt concept]
- Lamin B [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- Prelamin-A/C [NCIt concept]
Contains anatomical structure(s)
- Nuclear Lamin [NCIt concept]
Currated CISMeF NLP mapping
- nuclear lamina [MeSH Descriptor]
- nuclear lamina [MeSH concept]
False automatic mappings
- Nuclear lamina [FMA entity]
- nuclear lamina [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- Nuclear fibrous lamina (cell structure) [SNOMED CT concept]
- Nuclear lamina [FMA entity]
- nuclear fibrous lamina [SNOMED Notion]
- nuclear lamina [GO term]
- nuclear lamina [MeSH Descriptor]
- nuclear lamina [MeSH concept]

Keyword's position in hierarchy(ies) :

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