Delta(14)-Sterol Reductase LBR

Preferred Label : Delta(14)-Sterol Reductase LBR;

NCIt synonyms : LMN2R; EC 1.3.1.70; Delta-14-SR; C-14 Sterol Reductase; LBR; Lamin B Receptor; 3-Beta-Hydroxysterol Delta (14)-Reductase; Integral Nuclear Envelope Inner Membrane Protein; Sterol C14-Reductase; C14SR; Lamin-B Receptor;

NCIt definition : Delta(14)-sterol reductase LBR (615 aa, 71 kDa) is encoded by the human LBR gene. This protein is involved in anchoring the both nuclear lamina and heterochromatin to the inner nuclear membrane and in reduction of the C14-unsaturated bond of lanosterol.;

Détails

Origin ID

C202871;

UMLS CUI

C1623377;

OMIM relation
- Lamin b receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- LBR protein, human [MeSH Supplementary Concept]
- LBR protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- LBR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nuclear Inner Membrane [NCIt concept]
- Nuclear Lamina [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Protein [NCIt concept]
- Scaffolding Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Sterol Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

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