Sonic Hedgehog Protein

Preferred Label : Sonic Hedgehog Protein;

NCIt synonyms : HHG1; SHH; Sonic Hedgehog Homolog Protein; HHG-1; Sonic Hedgehog Homolog;

NCIt definition : Sonic hedgehog protein (462 aa, 50 kDa) is encoded by the human SHH gene. This protein plays a role in embryonic pattern formation.;

NCIt note : The C-terminal domain of sonic hedgehog protein has no signaling activity; however, it displays autoproteolysis and cholesterol transferase activities. Together these enzymatic activities catalyze the cleavage of the full-length protein and the covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling. (UniProt);

Details

Origin ID

C29962;

UMLS CUI

C0258846;

Currated CISMeF NLP mapping
- sonic hedgehog protein [MeSH concept]
OMIM relation
- Sonic hedgehog signaling molecule [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SHH protein, human [MeSH concept]
- SHH protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- SHH Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_chemical_classification
- Hedgehog Family [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Basal Cell Carcinoma Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- Glypican 3 Signaling Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Ptc1 Regulation of Cell Cycle Pathway [NCIt concept]
- Sonic Hedgehog Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Pattern Formation [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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