Serine Palmitoyltransferase 1

Preferred Label : Serine Palmitoyltransferase 1;

NCIt synonyms : Long Chain Base Biosynthesis Protein 1; Serine C-Palmitoyltransferase; EC 2.3.1.50; Serine-Palmitoyl-CoA Transferase 1; SPT1; LCB 1; SPT 1;

NCIt definition : Serine palmitoyltransferase 1 (473 aa, 53 kDa) is encoded by the human SPTLC1 gene. This protein plays a role in the biosynthesis of sphingolipids.;

NCIt note : Serine palmitoyltransferase 1 forms a heterodimer with either serine palmitoyltransferase 2 or serine palmitoyltransferase 3 to form the catalytic core of the serine palmitoyltransferase (SPT) complex. (UniProt);

Details

Origin ID

C127890;

UMLS CUI

C4284028;

Automatic exact mappings (from CISMeF team)
- Serine palmitoyltransferase, long-chain base subunit 1 [OMIM gene]
- long chain base biosynthesis protein 1 [MeSH concept]
- serine C-Palmitoyltransferase [MeSH concept]
- serine c-palmitoyltransferase [MeSH Descriptor]
OMIM relation
- Serine palmitoyltransferase, long-chain base subunit 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- SPTLC1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Lipid Metabolic Process [NCIt concept]
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

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