Furin - CISMeF

Preferred Label : Furin;

NCIt synonyms : PACE Protein; Paired Basic Amino Acid Cleaving Enzyme; Dibasic-Processing Enzyme; PACE; Paired Basic Amino Acid Residue-Cleaving Enzyme; EC 3.4.21.75; Furin Preproprotein;

NCIt definition : Furin (794 aa, 87 kDa) is encoded by the human FURIN gene. This protein is involved in endopeptidase activity and the secretory pathway.;

NCIt note : Furin is synthesized as a proenzyme that contains an autoinhibitory peptide sequence. This inhibitory peptide domain must be proteolytically processed twice to generate the active furin molecule. The first cleavage occurs autocatalytically in the endoplasmic reticulum but the inhibitory peptide remains bound until the second cleavage occurs in the trans-Golgi network. (UniProt); Furin cleaves protein substrates at RX(K/R)R consensus motifs.;

Details

Origin ID

C17902;

UMLS CUI

C1310542;

Automatic exact mappings (from CISMeF team)
- Furin, paired basic amino acid cleaving enzyme [OMIM gene]
- No pacing [ICD-11 Extension code]
- Pacing up and down (finding) [SNOMED CT concept]
- furin [COVID-19 Thesaurus concept]
- obsolete furin activity [GO term]
- pace [UCUM unit]
- pace of thought [ICF N3 Element]
Currated CISMeF NLP mapping
- furin [MeSH Descriptor]
- furin [MeSH concept]
False automatic mappings
- Furin (substance) [SNOMED CT concept]
OMIM relation
- Furin, paired basic amino acid cleaving enzyme [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FURIN protein, human [MeSH Supplementary Concept]
- FURIN protein, human [MeSH concept]
- Furin (substance) [SNOMED CT concept]
- furin [MeSH concept]
- furin [MeSH Descriptor]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FURIN Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glypican 3 Signaling Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Notch Proteolysis and Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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