Protein-Glutamine Gamma-Glutamyltransferase 2

Preferred Label : Protein-Glutamine Gamma-Glutamyltransferase 2;

NCIt synonyms : TTgase; TGC; TGase 2; Erythrocyte Transglutaminase; EC 2.3.2.13; hTG2; TGM2; Isopeptidase TGM2; Heart G Alpha(H); Protein-Glutamine Dopaminyltransferase TGM2; G(h); TGase C; hhG alpha(h); TGase-2; TGase H; Transglutaminase 2; Transglutaminase II; Protein-Glutamine Serotonyltransferase TGM2; Protein-Glutamine Histaminyltransferase TGM2; Protein-Glutamine Noradrenalinyltransferase TGM2; Transglutaminase C; TG(C); Transglutaminase-2; Transglutaminase H; TG2; TGase II; Protein G Alpha(H); Protein-Glutamine Deamidase TGM2;

NCIt related terms : TISSUE TRANSGLUTAMINASE; tTG;

NCIt definition : Protein-glutamine gamma-glutamyltransferase 2 (687 aa, 77 kDa) is encoded by the human TGM2 gene. This protein plays a role in both the induction of apoptosis and the formation of covalent bonds between peptide-bound glutamine and various primary amines.;

Alternative definition : CDISC: An antigen of the transglutaminase enzyme family and catalyzes the crosslinking of proteins with a molecular weight of approximate 78 kDa. It can be considered as an autoantigen and is commonly associated with the autoimmune disease celiac disease.;

NCIt note : Protein-glutamine gamma-glutamyltransferase 2 also has acetyltransferase (EC 2.3.1.-), peptidase (EC 3.4.-.-) and deamidase (EC 3.5.1.44) activities. (UniProt);

NCI Metathesaurus CUI : CL1786972;

Details

Origin ID

C186641;

UMLS CUI

C5565118;

Automatic exact mappings (from CISMeF team)
- Protein Glutamine gamma Glutamyltransferase 2 [MeSH Descriptor]
- Tissue transglutaminase [LOINC component]
- Transglutaminase 2 [OMIM gene]
- protein-glutamine gamma-glutamyltransferase activity [GO term]
- transglutaminase 2 [HGNC gene]
- transglutaminase 2 [MeSH concept]
OMIM relation
- Transglutaminase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TGM2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- TGM2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- GTPase-Activating Protein [NCIt concept]
- Transglutaminase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Huntington's Disease Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Peptide Metabolism [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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