" /> Protein O-GlcNAcase - CISMeF





Preferred Label : Protein O-GlcNAcase;

NCIt synonyms : Nuclear Cytoplasmic O-GlcNAcase and Acetyltransferase; NCOAT; Beta-N-Acetylglucosaminidase; N-Acetyl-Beta-D-Glucosaminidase; Bifunctional Protein NCOAT; N-Acetyl-Beta-Glucosaminidase; EC 3.2.1.169; MGEA5; O-GlcNAcase; O-Linked N-Acetylglucosaminidase; Beta-Hexosaminidase; Beta-N-Acetylhexosaminidase; OGA; Meningioma-Expressed Antigen 5;

NCIt definition : Protein O-GlcNAcase (916 aa, 103 kDa) is encoded by the human OGA gene. This protein plays a role in the hydrolysis of O-linkages between N-acetylglucosamine (GlcNAc) and serine or threonine protein residues.;

NCIt note : Caution from UniProt: The mouse and rat orthologs of protein O-GlcNAcase were initially identified as bi-functional proteins containing an N-terminal O-GlcNAcase domain and a C-terminal histone acetyltransferase domain. However, the residues for acetyl-CoA binding are not conserved in mammals. Additionally, the human protein does not bind acetyl-CoA nor does it possess histone acetyltranferase activity.;

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29/04/2024


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