" /> BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.944C T Mutation - CISMeF





Preferred Label : BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.944C T Mutation;

NCIt synonyms : BCR/ABL1 Fusion Gene with NM_005157.4:c.944C T; BCR/ABL Fusion Gene with NM_005157.5:c.944C T; BCR/ABL Fusion Gene with NM_005157.4:c.944C T; BCR/ABL1 Fusion Gene with ABL1 NM_005157.5:c.944C T; BCR::ABL1 Fusion Gene with ABL1 NM_005157.4:c.944C T Mutation;

NCIt definition : A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of a mutated form of the ABL1 gene. In this fusion gene there is a point mutation where cytosine has been substituted with thymine at nucleotide position 944 of the ABL1 gene. This mutation is associated with imatinib-resistant leukemias.;

NCIt note : The position of the point mutation is denoted by its location in the ABL1 cDNA sequence (NCBI Reference Sequence: NM_005157.4) and not its location in the fusion gene cDNA.;

SNP ID : rs121913459;

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23/05/2025


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