Leukemia, chronic myeloid

Preferred Label : Leukemia, chronic myeloid;

Symbol : CML;

CISMeF acronym : ACML; CML;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Leukemia, chronic myelogenous;

Included titles and symbols : Leukemia, chronic myeloid, atypical; ACML; Leukemia, philadelphia chromosome-positive, resistant to imatanib;

Inheritance : Somatic mutation;

Molecular basis : Translocation of cellular oncogene C-ABL (189980) to the BCR gene on chromosome 22 resulting in chimeric BRC-ABL gene;

Laboratory abnormalities : Low leukocyte alkaline phosphatase activity; Two alternative chimeric oncogene products called p210(BCR-ABL) and p185(BCR-ABL); Presence of the Philadelphia chromosome (translocation of 9q34 and 22q11) in greater than 95% of patients; Detection by RT-PCR, Southern blot analysis, and FISH for primary diagnosis and follow up for residual disease;

Prefixed ID : #608232;

Details

Origin ID

608232;

UMLS CUI

C0279543;

Automatic exact mappings (from CISMeF team)
- Atypical Chronic Myeloid Leukemia [NCIt concept]
- Atypical chronic myeloid leukemia [ORDO Disease]
- BCR activator of RhoGEF and GTPase [ORDO Gene]
- BCR activator of RhoGEF and GTPase [HGNC gene]
- BCR wt Allele [NCIt concept]
- Breakpoint Cluster Region Protein [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Chronic myeloid leukaemia, not elsewhere classified [ICD-11 Subcategory]
- Myelodysplastic-myeloproliferative neoplasm with neutrophilia (disorder) [SNOMED CT concept]
- N(6)-Carboxymethyllysine [NCIt concept]
- Smooth muscle cell [FMA entity]
- atypical chronic myeloid leukemia [DO Concept]
- chronic leukemia [DO Concept]
- immunity, cellular [MeSH Descriptor]
- leukemia, myeloid, chronic, atypical, bcr-abl negative [MeSH Descriptor]
- myocytes, smooth muscle [MeSH Descriptor]
Currated CISMeF NLP mapping
- CML [MedDRA LLT]
- Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
- Chronic myelogenous leukaemia [MedDRA LLT]
- Chronic myelogenous leukemia [PASCAL descriptor]
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia [MedDRA LLT]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukaemia [ICD-10 Sub-category (who)]
- Chronic myeloid leukaemia [MedDRA Preferred Term]
- Chronic myeloid leukemia [ORDO Disease]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia [ICD-9 code]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Chronic myeloid leukemia, BCR/ABL-positive [ICD-10 Sub-category]
- Chronic myeloid leukemia, NOS [ICD-O code]
- Leukaemias chronic myeloid [MedDRA High Level Term]
- Myeloid leukaemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- chronic myeloid leukemia [DO Concept]
- chronic myeloid leukemia [Disease (Nov.)]
- chronic myeloid leukemia [MedlinePlus Topic]
- chronic myeloid leukemia [SNOMED Notion]
- leukemia, myelogenous, chronic, BCR-ABL positive [MeSH concept]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
- myeloid leukemia [Blood Transfusion thesaurus concept]
DO Cross reference
- chronic myeloid leukemia [DO Concept]
False automatic mappings
- Circular Mil [NCIt concept]
Genes related to phenotype
- Abl protooncogene 1, nonreceptor tyrosine kinase [OMIM gene]
HPO term(s)
- Chronic myelogenous leukemia [HPO term]
- Ph-positive acute lymphoblastic leukemia [HPO term]
- Reduced leukocyte alkaline phosphatase [HPO term]
- Somatic mutation [HPO term]
ORDO concept(s)
- Chronic myeloid leukemia [ORDO Disease]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- CML [MedDRA LLT]
- Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
- Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive [NCIt concept]
- Chronic granulocytic leukaemia [MedDRA LLT]
- Chronic granulocytic leukemia [MedDRA LLT]
- Chronic myelocytic leukaemia [MedDRA LLT]
- Chronic myelocytic leukemia [MedDRA LLT]
- Chronic myelogenous leukaemia [MedDRA LLT]
- Chronic myelogenous leukemia [MedDRA LLT]
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia [PASCAL descriptor]
- Chronic myelogenous leukemia, BCR/ABL positive [ICD-O code]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukaemia [ICD-10 Sub-category (who)]
- Chronic myeloid leukaemia [MedDRA Preferred Term]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia [ORDO Disease]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Chronic myeloid leukemia (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukemia, NOS [ICD-O code]
- Leukaemia myelocytic chronic [MedDRA LLT]
- Leukaemias chronic myeloid [MedDRA High Level Term]
- Leukemia myelocytic chronic [MedDRA LLT]
- Myeloid leukaemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- Philadelphia chromosome positive chronic myelogenous leukemia (disorder) [SNOMED CT concept]
- Philadelphia chromosome positive chronic myeloid leukemia [Disease (Nov.)]
- chronic myeloid leukemia [SNOMED Notion]
- chronic myeloid leukemia [DO Concept]
- chronic myeloid leukemia [Disease (Nov.)]
- chronic myeloid leukemia [MedlinePlus Topic]
- leukemia, myelogenous, chronic, BCR-ABL positive [MeSH concept]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
Validated automatic mappings to BTNT
- Chronic myelogenous leukaemia, BCR-ABL1-positive [ICD-11 Subcategory]

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