Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive

Preferred Label : Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive;

NCIt synonyms : Ph' Positive Chronic Granulocytic Leukemia; Philadelphia Chromosome Positive Chronic Myelogenous Leukemia; Ph' Chromosome Positive Chronic Myelocytic Leukemia; Ph1 Chromosome Positive Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia t(9;22) (q34;q11), BCR/ABL Positive; Ph1 Chromosome Positive Chronic Myeloid Leukemia; Ph1 Positive Chronic Granulocytic Leukemia; Philadelphia Chromosome Positive Chronic Myeloid Leukemia; Ph' Chromosome Positive Chronic Myelogenous Leukemia; Ph' Chromosome Positive Chronic Myeloid Leukemia; Ph1 Chromosome Positive Chronic Myelocytic Leukemia; Philadelphia Chromosome Positive CML; Philadelphia Chromosome Positive Chronic Granulocytic Leukemia; Philadelphia Chromosome Positive Chronic Myelocytic Leukemia; Philadelphia Chromosome Positive, BCR::ABL1 Positive Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR::ABL1 Positive;

NCIt related terms : Chronic granulocytic leukemia, t(9;22)(q34;q11); Chronic myelogenous leukemia, Philadelphia chromosome (Ph 1) positive; Chronic myelogenous leukemia, Philadelphia chromosome positive; CML - Philadelphia chromosome; Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive; Chronic myelogenous leukemia, t(9;22)(q34;q11); Chronic granulocytic leukemia, BCR/ABL; Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia;

NCIt definition : A chronic myeloid leukemia characterised by the t(9;22)(q34;q11) chromosomal translocation, resulting in the presence of the Philadelphia chromosome and the BCR-ABL1 fusion gene.;

Neoplastic status : Malignant;

Codes from synonyms : 10009013;

Details

Origin ID

C9128;

UMLS CUI

C0279543;

Automatic exact mappings (from CISMeF team)
- Chronic myelogenous leukemia, BCR/ABL positive (morphologic abnormality) [Inactive SNOMED CT concept]
- Chronic myeloid leukemia, BCR/ABL-positive [ICD-10 Sub-category]
- Philadelphia chromosome positive chronic myelogenous leukemia (disorder) [SNOMED CT concept]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Fatigue [NCIt concept]
- Hepatomegaly [NCIt concept]
- Leukocytosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- CML [MedDRA LLT]
- Chronic granulocytic leukaemia [MedDRA LLT]
- Chronic granulocytic leukemia [MedDRA LLT]
- Chronic myelocytic leukaemia [MedDRA LLT]
- Chronic myelocytic leukemia [MedDRA LLT]
- Chronic myelogenous leukaemia [MedDRA LLT]
- Chronic myelogenous leukemia [MedDRA LLT]
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukaemia [MedDRA Preferred Term]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Chronic myeloid leukemia (morphologic abnormality) [SNOMED CT concept]
- Leukaemia myelocytic chronic [MedDRA LLT]
- Leukaemias chronic myeloid [MedDRA High Level Term]
- Leukemia myelocytic chronic [MedDRA LLT]
- Leukemia, chronic myeloid [OMIM Phenotype]
- Myeloid leukaemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- Philadelphia chromosome positive chronic myelogenous leukemia (disorder) [SNOMED CT concept]
- Philadelphia chromosome positive chronic myeloid leukemia [Disease (Nov.)]
- chronic myeloid leukemia [MedlinePlus Topic]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
Validated automatic mappings to NTBT
- Philadelphia chromosome positive chronic myeloid leukemia [Disease (Nov.)]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI CTEP SDC Chronic Myeloproliferative Disease Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- FGFR1 Gene Rearrangement [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Hypercellular Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Splenomegaly [NCIt concept]
disease_has_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_molecular_abnormality
- JAK-STAT Pathway Deregulation [NCIt concept]
- JUN Pathway Deregulation [NCIt concept]
- MYC Pathway Deregulation [NCIt concept]
- PI3K-AKT Pathway Deregulation [NCIt concept]
- RAS-RAF Pathway Deregulation [NCIt concept]
- p190 Fusion Protein Expression [NCIt concept]
- p210 Fusion Protein Expression [NCIt concept]
- p230 Fusion Protein Expression [NCIt concept]

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