Philadelphia Chromosome

Preferred Label : Philadelphia Chromosome;

NCIt synonyms : Ph; Philadelphia Translocation;

NCIt definition : A translocation between chromosomes 9 and 22. It is the hallmark for chronic myelogenous leukemia (CML).;

Alternative definition : NCI-GLOSS: An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.;

Codes from synonyms : CDR0000044179;

Details

Origin ID

C28452;

UMLS CUI

C0031526;

Automatic exact mappings (from CISMeF team)
- Finding of pH (finding) [SNOMED CT concept]
- Hydrogen ion concentration (observable entity) [SNOMED CT concept]
- Hydrogen-Ion concentration [MeSH Descriptor]
- Pallister-hall syndrome [OMIM Phenotype]
- Peliosis hepatis [ICD-11 Subcategory]
- Philadelphia chromosome [PASCAL descriptor]
- pH NOS [MedDRA LLT]
- ph+ (qualifier value) [SNOMED CT concept]
- ph++ (qualifier value) [SNOMED CT concept]
- ph+++ (qualifier value) [SNOMED CT concept]
- phenylalanine hydroxylase [ORDO Gene]
- physiology [MeSH Descriptor]
- posterior nucleus of hypothalamus [UBERON concept]
Semantic type(s)
- Pathologic Function [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 22 [NCIt concept]
- Human Chromosome 9 [NCIt concept]
is_cytogenetic_abnormality_of_disease
- Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 [NCIt concept]
- B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 [NCIt concept]
- B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Lymphoid Only Involvement [NCIt concept]
- B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Multilineage Involvement [NCIt concept]
- Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 [NCIt concept]
- Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive [NCIt concept]
- Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 [NCIt concept]
- Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 [NCIt concept]
is_not_cytogenetic_abnormality_of_disease
- Accelerated Phase Primary Myelofibrosis [NCIt concept]
- Atypical Chronic Myeloid Leukemia [NCIt concept]
- B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative [NCIt concept]
- Blast Phase Primary Myelofibrosis [NCIt concept]
- Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive [NCIt concept]
- Chronic Myelomonocytic Leukemia [NCIt concept]
- Chronic Myelomonocytic Leukemia with Eosinophilia [NCIt concept]
- Chronic Myelomonocytic Leukemia-0 [NCIt concept]
- Chronic Myelomonocytic Leukemia-1 [NCIt concept]
- Chronic Myelomonocytic Leukemia-2 [NCIt concept]
- Chronic Phase Primary Myelofibrosis [NCIt concept]
- Clonal Cytopenia with Monocytosis of Undetermined Significance [NCIt concept]
- Clonal Monocytosis of Undetermined Significance [NCIt concept]
- Early/Prefibrotic Primary Myelofibrosis [NCIt concept]
- Essential Thrombocythemia [NCIt concept]
- Myelodysplastic Chronic Myelomonocytic Leukemia [NCIt concept]
- Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy [NCIt concept]
- Myelodysplastic/Myeloproliferative Neoplasm with Isolated Isochromosome 17q [NCIt concept]
- Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified [NCIt concept]
- Myelodysplastic/Myeloproliferative Neoplasm with SF3B1 Mutation and Thrombocytosis [NCIt concept]
- Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified [NCIt concept]
- Myeloid Leukemia, Philadelphia-Negative [NCIt concept]
- Myeloproliferative Chronic Myelomonocytic Leukemia [NCIt concept]
- Myeloproliferative Neoplasm, BCR-ABL1 Negative [NCIt concept]
- Overt Primary Myelofibrosis [NCIt concept]
- Polycythemia Vera [NCIt concept]
- Polycythemia Vera, Polycythemic Phase [NCIt concept]
- Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase [NCIt concept]
- Post-Essential Thrombocythemia Myelofibrosis [NCIt concept]
- Primary Myelofibrosis [NCIt concept]
- Recurrent Atypical Chronic Myeloid Leukemia [NCIt concept]
- Recurrent B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative [NCIt concept]
- Recurrent Chronic Myelomonocytic Leukemia [NCIt concept]
- Recurrent Myelodysplastic/Myeloproliferative Neoplasm [NCIt concept]
- Recurrent Primary Myelofibrosis [NCIt concept]
- Refractory B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative [NCIt concept]
- Refractory Chronic Myelomonocytic Leukemia [NCIt concept]
- Refractory Myelodysplastic/Myeloproliferative Neoplasm [NCIt concept]
- Refractory Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase [NCIt concept]
- Refractory Post-Essential Thrombocythemia Myelofibrosis [NCIt concept]
- Refractory Primary Myelofibrosis [NCIt concept]
may_be_cytogenetic_abnormality_of_disease
- Recurrent Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
- Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
- Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
molecular_abnormality_involves_gene
- ABL1 Gene [NCIt concept]
- BCR Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]

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