Chronic Myelomonocytic Leukemia with Eosinophilia

Preferred Label : Chronic Myelomonocytic Leukemia with Eosinophilia;

NCIt synonyms : CMML with Eosinophilia;

NCIt definition : A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.;

Neoplastic status : Malignant;

Details

Origin ID

C36060;

UMLS CUI

C1333045;

Automatic exact mappings (from CISMeF team)
- Chronic myelomonocytic leukaemia with eosinophilia [ICD-11 More detail]
- Chronic myelomonocytic leukemia [ICD-10 Sub-category]
Disease excludes abnormal cell
- Toxic Neutrophil [NCIt concept]
Disease may have findings
- Basophilia [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Fatigue [NCIt concept]
- Fever [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Leukocytosis [NCIt concept]
- Night Sweats [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(5;12)(q31;p12) [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Extramedullary Hematopoiesis [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
- ETV6-PDGFRB Fusion Protein Expression [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts Under 20 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts Under 20 Percent of Peripheral Blood White Cells [NCIt concept]
- Bone Marrow Dysplasia Present [NCIt concept]
- Eosinophilia [NCIt concept]
- Immature Granulocytes in Peripheral Blood Under 10 Percent [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Monocytosis [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Hypolobated Neutrophil [NCIt concept]
- Large Atypical Platelet [NCIt concept]
- Megaloblast [NCIt concept]
- Micromegakaryocyte [NCIt concept]
- Neutrophil with Abnormal Cytoplasmic Granulation [NCIt concept]
- Ring Sideroblast [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 7q [NCIt concept]
- i(17q) [NCIt concept]
disease_may_have_molecular_abnormality
- NRAS Gene Mutation [NCIt concept]

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