NCIt definition : A phase of chronic myeloid leukemia, Philadelphia chromosome positive, BCR-ABL1 positive
in which the peripheral blood smear shows leukocytosis with neutrophils in different
stages of maturation, less than 2% blasts, and normal or increased platelet count.
Most patients have mild anemia. The bone marrow is hypercellular due to increased
numbers of neutrophils and their precursors, and blasts usually account for fewer
than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated
nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by
granulocytes.;