B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

Preferred Label : B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1;

NCIt synonyms : B-Cell Acute Lymphoblastic Leukemia with t(9;22)(q34;q11.2); BCR-ABL1; Philadelphia Positive Precursor Lymphoblastic Leukemia; Philadelphia Positive Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia with t(9;22)(q34;q11.2); BCR-ABL1; Acute Lymphoblastic Leukemia, Philadelphia Chromosome Positive; B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR::ABL1; B-Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1; B-Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR::ABL1; B-Acute Lymphoblastic Leukemia with BCR::ABL1 Fusion; B Acute Lymphoblastic Leukemia with BCR::ABL1 Fusion; B-Acute Lymphoblastic Leukemia with BCR-ABL1 Fusion; B Acute Lymphoblastic Leukemia with BCR-ABL1 Fusion;

NCIt definition : A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.;

Neoplastic status : Malignant;

Détails

Origin ID

C36312;

UMLS CUI

C1709527;

Automatic exact mappings (from CISMeF team)
- leukemia, lymphocytic, acute, L2 [MeSH concept]
- precursor cell lymphoblastic Leukemia-Lymphoma [MeSH Descriptor]
CISMeF manual mappings
- precursor B cell lymphoblastic leukemia, subtype t(9;22)(q34;q11) ABL/BCR [Disease (Nov.)]
Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Mature B-Lymphocyte [NCIt concept]
- Myeloid Cell [NCIt concept]
Disease may have findings
- Bone Pain [NCIt concept]
- Coarse Azurophilic Granules Present [NCIt concept]
- Extensive Bone Marrow and Blood Involvement [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Ph-positive acute lymphoblastic leukemia [HPO term]
- Philadelphia chromosome positive acute lymphoblastic leukemia [Disease (Nov.)]
- Philadelphia chromosome-positive acute lymphoblastic leukemia (disorder) [SNOMED CT concept]
- Philadelphia chromosome-positive acute lymphoblastic leukemia (morphologic abnormality) [SNOMED CT concept]
- precursor B cell lymphoblastic leukemia, subtype t(9;22)(q34;q11) ABL/BCR [Disease (Nov.)]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Blasts of Mixed Phenotype Present [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphoblast [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
- p190 Fusion Protein Expression [NCIt concept]
- p210 Fusion Protein Expression [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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