Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase

Preferred Label : Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase;

NCIt synonyms : Polycythemia Vera, Post-Polycythemic Myelofibrosis and Myeloid Metaplasia Stage; Polycythemia Vera, Spent Phase; Polycythemia Vera Post-Polycythemic Myelofibrosis and Myeloid Metaplasia Phase; Post-polycythemia Vera Myelofibrosis; Spent Phase and Post-Polycythemic Myelofibrosis; Post-PV MF;

NCIt definition : Progression of polycythemia vera characterized by decreased erythropoiesis and granulopoiesis, reticulin and collagen fibrosis of the bone marrow, leucoerythroblastic reaction in the peripheral blood, poikilocytosis, tear-drop shaped red blood cells, and splenomegaly.;

Neoplastic status : Malignant;

Details

Origin ID

C41233;

UMLS CUI

C3805232;

Currated CISMeF NLP mapping
- Myelofibrosis due to and following polycythemia vera (disorder) [SNOMED CT concept]
- Post polycythaemia vera myelofibrosis [MedDRA LLT]
- Post polycythemia vera myelofibrosis [MedDRA LLT]
Disease excludes abnormal cell
- Segmented Neutrophil [NCIt concept]
Disease excludes normal cell origin
- Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Hemorrhage [NCIt concept]
- Osteosclerosis [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Myelofibrosis due to and following polycythemia vera (disorder) [SNOMED CT concept]
- Post polycythaemia vera myelofibrosis [MedDRA LLT]
- Post polycythemia vera myelofibrosis [MedDRA LLT]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Eosinophilia [NCIt concept]
- Increased Red Cell Mass [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Neutrophilia [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Hyperchromatic Megakaryocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Tear-Drop Red Blood Cell [NCIt concept]
disease_has_finding
- Bone Marrow Fibrosis [NCIt concept]
- Leukoerythroblastic Reaction [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Poikilocytosis [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Multipotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Gain of Chromosome 9 [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 1p [NCIt concept]
- Loss of Chromosome 20q [NCIt concept]
disease_may_have_molecular_abnormality
- JAK2 Exon 12 Mutation [NCIt concept]
- JAK2 NP_004963.1:p.V617F [NCIt concept]

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