Overt Primary Myelofibrosis

Preferred Label : Overt Primary Myelofibrosis;

NCIt synonyms : Chronic Idiopathic Myelofibrosis, Fibrotic Stage; Chronic Idiopathic Myelofibrosis Fibrotic Stage; Primary Myelofibrosis, Fibrotic Stage; Primary Myelofibrosis, Overt Fibrotic Stage;

NCIt definition : Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.;

Neoplastic status : Malignant;

Détails

Origin ID

C41238;

UMLS CUI

C1516552;

Automatic exact mappings (from CISMeF team)
- Primary myelofibrosis [ORDO Disease]
- primary myelofibrosis [MeSH Descriptor]
Disease excludes abnormal cell
- Segmented Neutrophil [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Dyspnea [NCIt concept]
- Fatigue [NCIt concept]
- Hemorrhage [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Hypocellular Bone Marrow [NCIt concept]
- Leukocytosis [NCIt concept]
- Leukopenia [NCIt concept]
- Low Grade Fever [NCIt concept]
- Night Sweats [NCIt concept]
- Osteosclerosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Eosinophilia [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Neutrophilia [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
- Secondary Lesion [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Dacrocyte [NCIt concept]
- Hyperchromatic Megakaryocyte [NCIt concept]
- Large Atypical Platelet [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_disease
- Anemia [NCIt concept]
disease_has_finding
- Bone Marrow Fibrosis [NCIt concept]
- Granulocytes Increased in Bone Marrow [NCIt concept]
- Leukoerythroblastic Reaction [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Marked Bone Marrow Fibrosis [NCIt concept]
- Megakaryocytes Increased in Bone Marrow [NCIt concept]
- Myeloblasts Under 10 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Myeloblasts Under 10 Percent of Peripheral Blood White Cells [NCIt concept]
- Nucleated Red Blood Cells Present [NCIt concept]
- Poikilocytosis [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 20q [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]
- Partial Trisomy 1q [NCIt concept]

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