Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

Preferred Label : Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive;

NCIt synonyms : Refractory Accelerated Phase Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR::ABL1 Positive; Refractory Accelerated Phase Chronic Myeloid Leukemia; Refractory Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;

NCIt definition : Accelerated phase chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1799311;

Détails

Origin ID

C190787;

UMLS CUI

C5783937;

Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Basophilia [NCIt concept]
- Blasts 10-19 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10-19 Percent of Peripheral Blood White Cells [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Fatigue [NCIt concept]
- Hepatomegaly [NCIt concept]
- Leukocytosis [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Thrombocytosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- FGFR1 Gene Rearrangement [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Accelerated Phase [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Leukocytosis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Refractory Disease [NCIt concept]
- Splenomegaly [NCIt concept]
- Transformed Phase of Disease [NCIt concept]
disease_has_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome Y [NCIt concept]
- Monosomy 7 [NCIt concept]
- Philadelphia Chromosome [NCIt concept]
- Trisomy 8 [NCIt concept]
- i(17q) [NCIt concept]
- i(19) [NCIt concept]
- t(3;21)(q26;q22) [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_may_have_molecular_abnormality
- MECOM-RUNX1 Fusion Protein Expression [NCIt concept]
- p190 Fusion Protein Expression [NCIt concept]
- p210 Fusion Protein Expression [NCIt concept]
- p230 Fusion Protein Expression [NCIt concept]

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