t(3;21)(q26;q22)

Preferred Label : t(3;21)(q26;q22);

NCIt synonyms : t 3 21 q26 q22; t(3;21)(q26.2;q22);

NCIt definition : A cytogenetic abnormality that refers to the translocation of the long arm (q26) of chromosome 3 and the long arm (q22) of chromosome 21. It is associated with RUNX1/MECOM fusions, chronic myelogenous leukemia in blast crisis (BC-CML), myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).;

Details

Origin ID

C36606;

UMLS CUI

C1515763;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 21 [NCIt concept]
- Human Chromosome 3 [NCIt concept]
is_abnormality_of_gene
- RUNX1/MECOM Fusion Gene [NCIt concept]
is_cytogenetic_abnormality_of_disease
- Acute Myeloid Leukemia with t(3;21)(q26.2;q22.1); MECOM-RUNX1 [NCIt concept]
may_be_cytogenetic_abnormality_of_disease
- Recurrent Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
- Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
molecular_abnormality_involves_gene
- MECOM Gene [NCIt concept]
- RUNX1 Gene [NCIt concept]
- RUNX1/MECOM Fusion Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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