Primary Myelofibrosis

Preferred Label : Primary Myelofibrosis;

NCIt synonyms : AMM; Idiopathic Myelofibrosis; Idiopathic Bone Marrow Fibrosis; Chronic Idiopathic Myelofibrosis; PMF;

NCIt related terms : myelosclerosis with myeloid metaplasia; Agnogenic myeloid metaplasia;

NCIt definition : A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001);

Alternative definition : NCI-GLOSS: A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia.;

Neoplastic status : Malignant;

ICD-O code : 9961/3;

Codes from synonyms : CDR0000306486; CDR0000306490; CDR0000306489;

Details

Origin ID

C2862;

UMLS CUI

C0001815;

Automatic exact mappings (from CISMeF team)
- Agnogenic myeloid metaplasia [MedDRA LLT]
- Idiopathic myelofibrosis [ACR pathology]
- Myelofibrosis with myeloid metaplasia [ICD-11 More detail]
- Myeloid metaplasia (myelosclerosis) [ACR pathology]
- Myeloid metaplasia (myelosclerosis) [ACR pathology]
- Myelosclerosis with myeloid metaplasia [ICD-9 code]
- Primary myelofibrosis [MedDRA Preferred Term]
- Primary myelofibrosis [ICD-11 Extension code]
- drug approval [MeSH Descriptor]
- suicide, assisted [MeSH Descriptor]
Currated CISMeF NLP mapping
- Leucoerythroblastic anaemia [MedDRA LLT]
- Myelofibrosis [PASCAL descriptor]
- Myelofibrosis (disorder) [SNOMED CT concept]
- Myelofibrosis with myeloid metaplasia [TUV Term]
- Myelofibrosis with myeloid metaplasia [TUV Concept]
- Myelosclerosis with myeloid metaplasia [ICD-O code]
- Osteomyelofibrosis [ICD-10 Sub-category]
- Primary myelofibrosis [ICD-11 Subcategory]
- Primary myelofibrosis [ORDO Disease]
- Primary myelofibrosis (disorder) [SNOMED CT concept]
- Primary myelofibrosis (morphologic abnormality) [SNOMED CT concept]
- myelofibrosis [DO Concept]
- myeloid splenomegaly [MeSH concept]
- myeloid splenomegaly [MeSH Supplementary Concept]
- primary myelofibrosis [MeSH Descriptor]
- primary myelofibrosis [MeSH concept]
DO Cross reference
- myelofibrosis [DO Concept]
Disease excludes abnormal cell
- Segmented Neutrophil [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- MYELOSIS NON-LEUKAEMIC [WHO-ART Included Term]
- Myelofibrosis with myeloid metaplasia [ICD-9 code]
- Myelosclerosis with myeloid metaplasia [ICD-O code]
- Primary myelofibrosis [MedDRA Preferred Term]
- Primary myelofibrosis (disorder) [SNOMED CT concept]
- Primary myelofibrosis (morphologic abnormality) [SNOMED CT concept]
- primary myelofibrosis [MeSH concept]
- primary myelofibrosis [MeSH Descriptor]
Validated automatic mappings to NTBT
- myelofibrosis [Disease (Nov.)]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Chronic Myeloproliferative Disease Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Eosinophilia [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Neutrophilia [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Granulocytes Increased in Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Megakaryocytes Increased in Bone Marrow [NCIt concept]
- Myeloblasts Under 10 Percent of Bone Marrow Nucleated Cells [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 20q [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]
- Partial Trisomy 1q [NCIt concept]
disease_may_have_molecular_abnormality
- CALR Gene Mutation [NCIt concept]
- JAK2 Gene Mutation [NCIt concept]
- MPL Gene Mutation [NCIt concept]

Keyword's position in hierarchy(ies) :

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