Blast Phase Primary Myelofibrosis

Preferred Label : Blast Phase Primary Myelofibrosis;

NCIt synonyms : Leukemic Transformation of Primary Myelofibrosis;

NCIt definition : Transformation of primary myelofibrosis into acute myeloid leukemia, typically via accelerated phase primary myelofibrosis. Myeloblasts account for 20% or more of the peripheral blood white cells or the nucleated cells in the bone marrow.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1793054;

Détails

Origin ID

C188318;

UMLS CUI

C5707710;

Disease excludes abnormal cell
- Segmented Neutrophil [NCIt concept]
Disease may have findings
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 20 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Chronic Clinical Course [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Eosinophilia [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Neutrophilia [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
- Secondary Lesion [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blast Phase [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Granulocytes Increased in Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Megakaryocytes Increased in Bone Marrow [NCIt concept]
- Myeloblasts Under 10 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Transformed Phase of Disease [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 20q [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]
- Partial Trisomy 1q [NCIt concept]

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