Early/Prefibrotic Primary Myelofibrosis

Preferred Label : Early/Prefibrotic Primary Myelofibrosis;

NCIt synonyms : Primary Myelofibrosis, Prefibrotic Stage; Chronic Idiopathic Myelofibrosis Prefibrotic Stage; Primary Myelofibrosis, Prefibrotic/Early Stage; Pre-PMF; Early/Prefibrotic Stage PMF; Early/Prefibrotic Stage Primary Myelofibrosis; Prefibrotic/Early Primary Myelofibrosis;

NCIt definition : Primary myelofibrosis characterized by bone marrow hypercellularity and the presence of atypical megakaryocytes. There is no increase in the percentage of myeloblasts and no significant increase in reticulin or collagen fibrosis in the bone marrow.;

Neoplastic status : Malignant;

Details

Origin ID

C41237;

UMLS CUI

C1516553;

Automatic exact mappings (from CISMeF team)
- cellular phase chronic idiopathic myelofibrosis [DO Concept]
DO Cross reference
- cellular phase chronic idiopathic myelofibrosis [DO Concept]
Disease excludes abnormal cell
- Segmented Neutrophil [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Hepatomegaly [NCIt concept]
- Immature Granulocytes in Peripheral Blood Increased [NCIt concept]
- Leukocytosis [NCIt concept]
- Minimal Reticulin Fibrosis of the Bone Marrow [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytosis [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- cellular phase chronic idiopathic myelofibrosis [DO Concept]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Eosinophilia [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Neutrophilia [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Large Megakaryocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Granulocytes Increased in Bone Marrow [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Megakaryocytes Increased in Bone Marrow [NCIt concept]
- Myeloblasts Under 10 Percent of Bone Marrow Nucleated Cells [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Large Atypical Platelet [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 20q [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]
- Partial Trisomy 1q [NCIt concept]
disease_may_have_molecular_abnormality
- CALR Gene Mutation [NCIt concept]
- JAK2 Gene Mutation [NCIt concept]
- MPL Gene Mutation [NCIt concept]

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