Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive

Preferred Label : Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive;

NCIt synonyms : Ph- Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative Chronic Myelocytic Leukemia; Ph' Chromosome Negative Chronic Granulocytic Leukemia; Philadelphia Chromosome Negative Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative CML; Ph' Chromosome Negative Chronic Myelocytic Leukemia; Ph Negative Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative Chronic Myeloid Leukemia; Philadelphia Chromosome Negative Chronic Granulocytic Leukemia; Ph' Chromosome Negative Chronic Myeloid Leukemia; Ph- CML; Ph Negative CML; Ph1 Chromosome Negative Chronic Myelocytic Leukemia; Philadelphia Chromosome Negative BCR-ABL1 Positive Chronic Myelogenous Leukemia; Ph' Negative Chronic Granulocytic Leukemia; Ph1 Chromosome Negative Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative, BCR::ABL1 Positive Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR::ABL1 Positive;

NCIt definition : A chronic myeloid leukemia which does not have the characteristic t(9;22)(q34;q11.2) translocation but it has either a variant translocation or a cryptic translocation that can not be detected by conventional cytogenetic analysis. In such cases the BCR-ABL1 fusion gene is always detected by RT-PCR, FISH, or Southern blot analysis.;

Neoplastic status : Malignant;

Details

Origin ID

C9129;

UMLS CUI

C0279549;

Automatic exact mappings (from CISMeF team)
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
- leukemia, myeloid, chronic, atypical, bcr-abl negative [MeSH Descriptor]
Currated CISMeF NLP mapping
- Philadelphia chromosome negative chronic myelogenous leukemia (disorder) [SNOMED CT concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Fatigue [NCIt concept]
- Hepatomegaly [NCIt concept]
- Leukocytosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Myelodysplastic-myeloproliferative neoplasm with neutrophilia (disorder) [SNOMED CT concept]
- Philadelphia chromosome negative chronic myelogenous leukemia (disorder) [SNOMED CT concept]
- Philadelphia chromosome negative chronic myeloid leukemia [Disease (Nov.)]
Validated automatic mappings to NTBT
- Chronic myeloid leukemia [ORDO Disease]
- Philadelphia chromosome negative chronic myeloid leukemia [Disease (Nov.)]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- FGFR1 Gene Rearrangement [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Hypercellular Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Splenomegaly [NCIt concept]
disease_has_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]

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