Chronic Myelomonocytic Leukemia

Preferred Label : Chronic Myelomonocytic Leukemia;

NCIt synonyms : CMML;

NCIt related terms : Chronic Myelomonocytic Leukemia (CMML);

NCIt definition : A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement.;

Alternative definition : NCI-GLOSS: A slowly progressing type of myelodysplastic/myeloproliferative disease in which too many myelomonocytes (a type of white blood cell) are in the bone marrow, crowding out other normal blood cells, such as other white blood cells, red blood cells, and platelets.;

Neoplastic status : Malignant;

ICD-O code : 9945/3;

Codes from synonyms : CDR0000367436; CDR0000367437; 10009018;

Details

Origin ID

C3178;

UMLS CUI

C0023480;

Automatic exact mappings (from CISMeF team)
- Chronic myelomonocytic leukemia [ICD-10 Sub-category]
- Juvenile myelomonocytic leukemia [OMIM Phenotype]
Currated CISMeF NLP mapping
- Chronic myelomonocytic leukaemia [ICD-11 Category]
- Chronic myelomonocytic leukaemia [MedDRA Preferred Term]
- Chronic myelomonocytic leukemia [PASCAL descriptor]
- Chronic myelomonocytic leukemia [HPO term]
- Chronic myelomonocytic leukemia [ORDO Disease]
- Chronic myelomonocytic leukemia [MedDRA LLT]
- Chronic myelomonocytic leukemia (morphologic abnormality) [SNOMED CT concept]
- chronic myelomonocytic leukemia [DO Concept]
- chronic myelomonocytic leukemia [Disease (Nov.)]
- leukemia, myelomonocytic, chronic [MeSH Descriptor]
- leukemia, myelomonocytic, chronic [MeSH concept]
DO Cross reference
- chronic myelomonocytic leukemia [DO Concept]
Disease excludes abnormal cell
- Toxic Neutrophil [NCIt concept]
Disease may have findings
- Basophilia [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Fatigue [NCIt concept]
- Fever [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Leukocytosis [NCIt concept]
- Night Sweats [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytosis [NCIt concept]
- Weight Loss [NCIt concept]
False automatic mappings
- Chronic myelomonocytic leukaemia (in remission) [MedDRA Preferred Term]
- Chronic myelomonocytic leukemia (disorder) [SNOMED CT concept]
- Chronic myelomonocytic leukemia (in remission) [MedDRA LLT]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Chronic myelomonocytic leukaemia [MedDRA Preferred Term]
- Chronic myelomonocytic leukaemia [ICD-11 Category]
- Chronic myelomonocytic leukemia [ORDO Disease]
- Chronic myelomonocytic leukemia [MedDRA LLT]
- Chronic myelomonocytic leukemia [ICD-10 Sub-category]
- Chronic myelomonocytic leukemia [HPO term]
- Chronic myelomonocytic leukemia [PASCAL descriptor]
- Chronic myelomonocytic leukemia (disorder) [SNOMED CT concept]
- Chronic myelomonocytic leukemia (morphologic abnormality) [SNOMED CT concept]
- Chronic myelomonocytic leukemia, NOS [ICD-O code]
- chronic myelomonocytic leukemia [DO Concept]
- chronic myelomonocytic leukemia [Disease (Nov.)]
- leukemia, myelomonocytic, chronic [MeSH Descriptor]
- leukemia, myelomonocytic, chronic [MeSH concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Myelodysplastic/Myeloproliferative Disease Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- Philadelphia Chromosome [NCIt concept]
- t(9;22)(q34.1;q11.2) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Extramedullary Hematopoiesis [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_gene
- NRAS Gene [NCIt concept]
- NRAS wt Allele [NCIt concept]
disease_has_finding
- Blasts Under 20 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts Under 20 Percent of Peripheral Blood White Cells [NCIt concept]
- Bone Marrow Dysplasia Present [NCIt concept]
- Immature Granulocytes in Peripheral Blood Under 10 Percent [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Monocytosis [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Hypolobated Neutrophil [NCIt concept]
- Large Atypical Platelet [NCIt concept]
- Megaloblast [NCIt concept]
- Micromegakaryocyte [NCIt concept]
- Neutrophil with Abnormal Cytoplasmic Granulation [NCIt concept]
- Ring Sideroblast [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 8 [NCIt concept]
- Loss of Chromosome 7q [NCIt concept]
- i(17q) [NCIt concept]
disease_may_have_molecular_abnormality
- NRAS Gene Mutation [NCIt concept]
may_be_associated_disease_of_disease
- Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia [NCIt concept]

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