" /> Sorafenib Tosylate - CISMeF





Preferred Label : Sorafenib Tosylate;

NCIt synonyms : BAY 43-9006 Tosylate; 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate; BAY 43-9006;

NCIt related terms : sorafenib; Nexavar;

NCIt definition : The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.;

Alternative definition : NCI-GLOSS: A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.;

UNII : 5T62Q3B36J;

CAS number : 475207-59-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 475207-59-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nexavar;

Molecule name : BAY 54-9085;

Chemical formula : C21H16ClF3N4O3.C7H8O3S;

NSC code : 724772;

ChEBI ID : CHEBI:50928;

Codes from synonyms : 32161; CDR0000390251; CDR0000470244; CDR0000509041;

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07/05/2024


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