Sorafenib Tosylate

Preferred Label : Sorafenib Tosylate;

NCIt synonyms : BAY 43-9006 Tosylate; 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate; BAY 43-9006;

NCIt related terms : sorafenib; Nexavar;

NCIt definition : The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.;

Alternative definition : NCI-GLOSS: A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.;

UNII : 5T62Q3B36J;

CAS number : 475207-59-1;

Drug name : Nexavar;

Molecule name : BAY 54-9085; BAY 54 9085; BAY-54-9085;

Chemical formula : C21H16ClF3N4O3.C7H8O3S;

NSC code : 724772;

ChEBI ID : CHEBI:50928;

Codes from synonyms : 32161; CDR0000390251; CDR0000470244; CDR0000509041;

Details

Origin ID

C2194;

UMLS CUI

C1676709;

Automatic exact mappings (from CISMeF team)
- BAY 43-9006 [MeSH concept]
See also inter- (CISMeF)
- Product containing sorafenib (medicinal product) [SNOMED CT concept]
- advanced liver cancer [Disease (Nov.)]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- SORAfenib [LOINC component]
- Sorafenib [MeSH Descriptor]
- Sorafenib [SMS substance]
- Sorafenib (substance) [SNOMED CT concept]
- sorafenib [MeSH concept]
chemical_or_drug_affects_gene_product
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Sorafenib [NCIt concept]
has_target
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor Beta [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_component_of_chemotherapy_regimen
- Azacitidine/Sorafenib Regimen [NCIt concept]
- Decitabine/Sorafenib Regimen [NCIt concept]
- Everolimus/Sorafenib Regimen [NCIt concept]
- Sorafenib Regimen [NCIt concept]
- Sorafenib/Topotecan Regimen [NCIt concept]
is_salt_form_of
- Sorafenib [NCIt concept]

Keyword's position in hierarchy(ies) :

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