Sorafenib - CISMeF

Preferred Label : Sorafenib;

MeSH definition : A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.;

MeSH hyponym : BAY 43 9006; BAY 439006; Sorafenib N Oxide; BAY 673472; BAY 545 9085; BAY 5459085; BAY-545-9085; BAY5459085; 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic acid methyamide-4-methylbenzenesulfonate;

MeSH CAS label : 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-;

MeSH Related Number : 5T62Q3B36J; 5XYK65KIGD;

Wikipedia link : https://en.wikipedia.org/wiki/Sorafenib;

UNII : 9ZOQ3TZI87;

Details

Origin ID

D000077157;

UMLS CUI

C1516119;

ATC code(s)
- sorafenib [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
MeSH indexing information
- raf kinases [MeSH Descriptor]
- receptors, vascular endothelial growth factor [MeSH Descriptor]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- protein kinase inhibitors [MeSH Descriptor]
Record concept(s)
- BAY 43-9006 [MeSH concept]
- BAY 545-9085 [MeSH concept]
- BAY-673472 [MeSH concept]
- Sorafenib N-Oxide [MeSH concept]
- nexavar [MeSH concept]
- sorafenib [MeSH concept]
- sorafenib tosylate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- Sorafenib Tosylate [NCIt concept]
- Sorafenib tosylate (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients