NCIt synonyms : MLN 518 Sulfate; CT53518 Sulfate; MLN518 Sulfate;
NCIt definition : The sulfate salt form of tandutinib, a piperazinyl quinazoline receptor tyrosine kinase
inhibitor with antineoplastic activity. Upon administration, tandutinib inhibits the
autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived
growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation
and inducing apoptosis.;