" /> Dasatinib - CISMeF





Preferred Label : Dasatinib;

NCIt synonyms : Dasatinib Hydrate; Dasatinib Monohydrate; 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-, Monohydrate;

NCIt related terms : BMS-354825; Sprycel;

NCIt definition : An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.;

Alternative definition : NCI-GLOSS: A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. BMS-354825 is also being studied in the treatment of certain other blood diseases and types of cancer. BMS-354825 binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor.;

UNII : RBZ1571X5H;

InChIKey : XHXFZZNHDVTMLI-UHFFFAOYSA-N;

CAS number : 863127-77-9;

Drug name : Sprycel;

Molecule name : BMS-354825; BMS 354825;

Chemical formula : C22H26ClN7O2S.H2O;

NSC code : 732517;

Codes from synonyms : CDR0000340926; CDR0000484435; CDR0000508645; 32181; 142;

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29/05/2025


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