Dasatinib - CISMeF

Preferred Label : Dasatinib;

NCIt synonyms : Dasatinib Hydrate; Dasatinib Monohydrate; 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-, Monohydrate;

NCIt related terms : BMS-354825; Sprycel;

NCIt definition : An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.;

Alternative definition : NCI-GLOSS: A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. BMS-354825 is also being studied in the treatment of certain other blood diseases and types of cancer. BMS-354825 binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor.;

UNII : RBZ1571X5H;

InChIKey : XHXFZZNHDVTMLI-UHFFFAOYSA-N;

CAS number : 863127-77-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 863127-77-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Sprycel;

Molecule name : BMS-354825;

Chemical formula : C22H26ClN7O2S.H2O;

NSC code : 732517;

Codes from synonyms : CDR0000340926; CDR0000484435; CDR0000508645; 32181; 142;

Details

Origin ID

C38713;

UMLS CUI

C1455147;

CISMeF manual mappings
- Dasatinib [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dasatinib [MeSH Descriptor]
- Dasatinib (substance) [SNOMED CT concept]
- Product containing dasatinib (medicinal product) [SNOMED CT concept]
- dasatinib [Substance BNPC]
- dasatinib [ATC Code]
- dasatinib [MeSH concept]
- dasatinib monohydrate [International Nonproprietary Name]
Validated automatic mappings to BTNT
- dasatinib monohydrate [International Nonproprietary Name]
chemical_or_drug_affects_gene_product
- SRC Family Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- BCR/ABL1 Fusion Protein [NCIt concept]
- Ephrin Type-A Receptor 2 [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor Beta [NCIt concept]
- Tyrosine-Protein Kinase CSK [NCIt concept]
is_component_of_chemotherapy_regimen
- Dasatinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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