fusion proteins, bcr-abl

Preferred Label : fusion proteins, bcr-abl;

MeSH definition : Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.;

MeSH synonym : bcr-abl fusion proteins; bcr abl fusion proteins; fusion proteins, bcr abl; Bcr-Abl tyrosine kinase; bcr abl tyrosine kinase; kinase, Bcr-Abl tyrosine; tyrosine kinase, Bcr-Abl; bcr-abl Fusion Protein; Fusion Protein, bcr-abl; Protein, bcr-abl Fusion; bcr abl Fusion Protein;

CISMeF synonym : proteins, bcr-abl fusion;

MeSH hyponym : oncogene protein p185(bcr-abl); oncogene protein p230(bcr-abl); oncogene protein p190(bcr-abl); oncogene protein p210(bcr-abl); p190(bcr-abl) Fusion Proteins; p230(bcr-abl) Fusion Proteins; p185(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins;

Registry Number MeSH : EC 2.7.10.2;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D016044;

UMLS CUI

C0004891;

ATC code(s)
- BCR-ABL tyrosine kinase inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- BCR/ABL1 Fusion Protein p190 [NCIt concept]
- BCR/ABL1 Fusion Protein p210 [NCIt concept]
- BCR/ABL1 Fusion Protein p230 [NCIt concept]
- Oncogene protein P190, BCR-ABL (substance) [SNOMED CT concept]
- Oncogene protein P210, BCR-ABL (substance) [SNOMED CT concept]
- oncogene protein p190, bcr-abl [SNOMED Notion]
- oncogene protein p210, bcr-abl [SNOMED Notion]
Currated CISMeF NLP mapping
- BCR/ABL [OBSOLETE LOINC component]
- BCR/ABL1 Fusion Protein [NCIt concept]
- Fusion protein BCR-ABL (substance) [SNOMED CT concept]
- fusion protein bcr-abl [SNOMED Notion]
Record concept(s)
- fusion proteins, bcr-abl [MeSH concept]
- oncogene protein p185(bcr-abl) [MeSH concept]
- oncogene protein p190(bcr-abl) [MeSH concept]
- oncogene protein p210(bcr-abl) [MeSH concept]
- oncogene protein p230(bcr-abl) [MeSH concept]
Related MeSH Supplementary Concept(s)
- BCR-ABL1 fusion protein, human [MeSH Supplementary Concept]
- abl-bcr fusion protein, human [MeSH Supplementary Concept]
See also
- Proto-Oncogene proteins c-abl [MeSH Descriptor]
- genes, abl [MeSH Descriptor]
- philadelphia chromosome [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BCR/ABL1 Fusion Protein [NCIt concept]
- Fusion protein BCR-ABL (substance) [SNOMED CT concept]
- fusion protein bcr-abl [SNOMED Notion]

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