Tyrosine Kinase Inhibitor

Preferred Label : Tyrosine Kinase Inhibitor;

NCIt synonyms : PTK Inhibitors; Protein Tyrosine Kinase Inhibitors; TK Inhibitors;

CISMeF acronym : TKI;

NCIt definition : Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals including cell proliferation. Inhibition of tyrosine kinase may result in inhibition of cell growth and cell proliferation.;

Alternative definition : NCI-GLOSS: A drug that interferes with cell communication and growth and may prevent tumor growth. Some tyrosine kinase inhibitors are used to treat cancer.;

ChEBI ID : CHEBI:38637;

Codes from synonyms : CDR0000044833;

Details

Origin ID

C1967;

UMLS CUI

C1268567;

Automatic exact mappings (from CISMeF team)
- IL2 inducible T cell kinase [ORDO Gene]
See also inter- (CISMeF)
- Product containing protein-tyrosine kinase inhibitor (product) [SNOMED CT concept]
- Protein-tyrosine kinase inhibitor (disposition) [SNOMED CT concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing protein-tyrosine kinase inhibitor (product) [SNOMED CT concept]
- Substance with protein-tyrosine kinase inhibitor mechanism of action (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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