janus kinases - CISMeF

Preferred Label : janus kinases;

MeSH definition : A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.;

MeSH synonym : kinases, janus; JAK Kinases; kinases, jak; Janus Kinase; Kinase, Janus;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.2;

Wikipedia link : https://en.wikipedia.org/wiki/Janus kinases;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D053612;

UMLS CUI

C0597721;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Wee1-Like Protein Kinase [NCIt concept]
Currated CISMeF NLP mapping
- Janus Kinase Family [NCIt concept]
- Janus kinase [COVID-19 Thesaurus concept]
Indexing information
- INCB 16562 [MeSH Supplementary Concept]
- ruxolitinib [MeSH Supplementary Concept]
Record concept(s)
- janus kinases [MeSH concept]
Related MeSH Supplementary Concept(s)
- hop protein, Drosophila [MeSH Supplementary Concept]
See also
- src homology domains [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Janus Kinase Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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