Janus Kinase Family

Preferred Label : Janus Kinase Family;

NCIt synonyms : Janus Kinase; JAK Family; JAK;

NCIt definition : A family of intracellular, non-receptor tyrosine-protein kinases. These enzymes transduce signals from certain cytokine receptors by phosphorylating and activating members of the Signal Transducer and Activator of Transcription (STAT) family of transcription factor proteins.;

NCIt note : Humans express four Janus kinase family proteins.;

Details

Origin ID

C129387;

UMLS CUI

C0597721;

Automatic exact mappings (from CISMeF team)
- janus kinases [MeSH concept]
- protein tyrosine kinase activity [GO term]
Currated CISMeF NLP mapping
- Janus kinase [COVID-19 Thesaurus concept]
- janus kinases [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- janus kinases [MeSH Descriptor]
- janus kinases [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Kinase Family Gene [NCIt concept]
gene_product_has_biochemical_function
- Phosphotransferase [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
is_chemical_classification_of_gene_product
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients