Proto-Oncogene proteins c-abl

Preferred Label : Proto-Oncogene proteins c-abl;

MeSH definition : Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.;

MeSH synonym : abl, proto-oncogene proteins; proto-oncogene proteins abl; abl proto oncogene products; proto-oncogene products, abl; abl proto oncogene proteins; products, abl proto-oncogene; proteins abl, proto-oncogene; proto-oncogene proteins, abl; proto oncogene proteins abl; c-abl, proto-oncogene proteins; c-abl proteins; c abl proteins; abl proto-oncogene products; abl proto-oncogene proteins; proto oncogene proteins c abl;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.2;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D016315;

UMLS CUI

C0080064;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Wee1-Like Protein Kinase [NCIt concept]
Record concept(s)
- Proto-Oncogene proteins c-abl [MeSH concept]
Related MeSH Supplementary Concept(s)
- ABL-1 protein, C elegans [MeSH Supplementary Concept]
- ABL1 protein, human [MeSH Supplementary Concept]
See also
- fusion proteins, bcr-abl [MeSH Descriptor]
- genes, abl [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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