Bosutinib - CISMeF

Preferred Label : Bosutinib;

NCIt synonyms : 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-Anilino-3-quinolinecarbonitrile; 4-Anilinobenzo(g)quinoline-3-carbonitrile;

NCIt related terms : SKI-606;

NCIt definition : A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.;

UNII : 5018V4AEZ0;

InChIKey : UBPYILGKFZZVDX-UHFFFAOYSA-N;

CAS number : 380843-75-4;

Molecule name : SKI 606; SKI-606;

Chemical formula : C26H29Cl2N5O3;

ChEBI ID : CHEBI:39112;

Codes from synonyms : 32145; 76;

Details

Origin ID

C60809;

UMLS CUI

C1831731;

Automatic exact mappings (from CISMeF team)
- bosutinib [ATC Code]
CISMeF manual mappings
- Bosutinib (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Bosutinib [ICD-11 Extension code]
- Bosutinib [SMS substance]
- bosutinib [International Nonproprietary Name]
- bosutinib [MeSH concept]
- bosutinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Bosutinib (substance) [SNOMED CT concept]
- Product containing bosutinib (medicinal product) [SNOMED CT concept]
- bosutinib [International Nonproprietary Name]
- bosutinib [ATC Code]
- bosutinib [MeSH Supplementary Concept]
- bosutinib [MeSH concept]
chemical_or_drug_affects_gene_product
- Receptor Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- BCR/ABL1 Fusion Protein [NCIt concept]
is_component_of_chemotherapy_regimen
- Bosutinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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