" /> Imatinib - CISMeF





Preferred Label : Imatinib;

NCIt synonyms : 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide; Imatinib Base;

NCIt definition : An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins.;

UNII : BKJ8M8G5HI;

InChIKey : KTUFNOKKBVMGRW-UHFFFAOYSA-N;

CAS number : 152459-95-5;

Chemical formula : C29H31N7O;

ChEBI ID : CHEBI:45783;

Codes from synonyms : 269;

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29/05/2025


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