Preferred Label : Nilotinib Hydrochloride Monohydrate;
NCIt synonyms : Nilotinib Monohydrochloride Monohydrate; 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide,
Monohydrochloride;
NCIt related terms : Tasigna;
NCIt definition : The monohydrate monohydrochloride form of nilotinib, an orally bioavailable aminopyrimidine-derivative
Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome
imatinib resistance resulting from Bcr-Abl kinase mutations, upon administration,
nilotinib binds to and stabilizes the inactive conformation of the kinase domain of
the Abl portion of the Bcr-Abl fusion protein, resulting in the inhibition of the
constitutive kinase activity of Bcr-Abl protein. This inhibits the Bcr-Abl-mediated
proliferation of Philadelphia chromosome-positive (Ph ) chronic myeloid leukemia (CML)
cells. Nilotinib also inhibits the receptor tyrosine kinases platelet-derived growth
factor receptor (PDGF-R; PDGFR), mast/stem cell growth factor receptor Kit (c-Kit),
and, to a lesser extent, colony-stimulating factor 1 receptor (CSF-1R; CSF1R), and
discoidin domain-containing receptor 1 (DDR1).;
UNII : 5JHU0N1R6K;
InChIKey : YCBPQSYLYYBPDW-UHFFFAOYSA-N;
CAS number : 923288-90-8;
Drug name : Tasigna;
Molecule name : AMN 107; AMN-107;
Chemical formula : C28H22F3N7O.HCl.H2O;
Codes from synonyms : CDR0000581140;
Origin ID : C95229;
UMLS CUI : C1966375;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
