NCIt definition : A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic
activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors
(VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R),
which may result in inhibition of angiogenesis in tumors in which these receptors
are upregulated.;
Alternative definition : NCI-GLOSS: A drug that is used to treat kidney cancer and is being studied in the
treatment of other types of cancer. It may prevent the growth of new blood vessels
that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a
type of antiangiogenesis agent.;