Preferred Label : Bezuclastinib;
NCIt synonyms : c-Kit Inhibitor PLX9486;
NCIt definition : An orally bioavailable protein tyrosine kinase inhibitor of mutated forms of the tumor-associated
antigen mast/stem cell factor receptor c-Kit (SCFR), with potential antineoplastic
activity. Upon oral administration, bezuclastinib binds to and inhibits specific c-Kit
mutants. This may result in an inhibition of tumor cell proliferation in cancer cell
types that overexpress these c-Kit mutations. c-Kit, a transmembrane protein and receptor
tyrosine kinase, is overexpressed in solid tumors and hematological malignancies;
it plays a key role in the regulation of cell differentiation and proliferation.;
UNII : 2ROQ545LAG;
CAS number : 1616385-51-3;
Molecule name : PLX9486; CGT 9486; CGT-9486;
Origin ID : C121647;
UMLS CUI : C5554531;
Semantic type(s)
- concept_is_in_subset
- has_target
