NCIt related terms : Anti-c-KIT Monoclonal Antibody KTN0158; CDX-0158;
NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody against the stem cell factor
receptor c-Kit (SCFR; KIT; CD117), with potential antineoplastic and anti-allergic
activities. Upon administration, the anti-c-KIT monoclonal antibody CDX 0158 binds
to and inhibits the activation of the cell surface antigen c-Kit. This leads to an
inhibition of the activation of c-KIT-mediated signal transduction pathways and inhibits
cell proliferation in cancer cells expressing c-Kit. In mast cells, inhibition of
c-KIT and c-KIT-mediated signaling prevents mast cell activation, degranulation and
subsequent cytokine release. c-Kit, a transmembrane protein and receptor tyrosine
kinase, is overexpressed in various cell types, including certain cancer cells and
mast cells; it plays a key role in the regulation of cell differentiation and proliferation.;
UNII : DF2O3JG5D2;
Molecule name : KTN-0158; KTN 0158; CDX 0158; CDX-0158;
Semantic type(s)