Pexidartinib - CISMeF

Preferred Label : Pexidartinib;

NCIt synonyms : 3-Pyridinemethanamine, N-(5-((5-chloro-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)-2-pyridinyl)-6-(trifluoromethyl)-;

NCIt definition : A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.;

UNII : 6783M2LV5X;

InChIKey : JGWRKYUXBBNENE-UHFFFAOYSA-N;

CAS number : 1029044-16-3;

Molecule name : PLX-3397; CML-261; PLX 3397;

Codes from synonyms : 25485;

Details

Origin ID

C88303;

UMLS CUI

C4287804;

Automatic exact mappings (from CISMeF team)
- Product containing pexidartinib (medicinal product) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Pexidartinib (substance) [SNOMED CT concept]
- pexidartinib [MeSH concept]
- pexidartinib [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- pexidartinib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pexidartinib (substance) [SNOMED CT concept]
- Product containing pexidartinib (medicinal product) [SNOMED CT concept]
- pexidartinib [MeSH Supplementary Concept]
- pexidartinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Pexidartinib Hydrochloride [NCIt concept]
has_target
- Macrophage Colony-Stimulating Factor 1 Receptor [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
is_free_acid_or_base_form_of
- Pexidartinib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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