" /> Pexidartinib - CISMeF





Preferred Label : Pexidartinib;

NCIt synonyms : 3-Pyridinemethanamine, N-(5-((5-chloro-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)-2-pyridinyl)-6-(trifluoromethyl)-;

NCIt definition : A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.;

UNII : 6783M2LV5X;

InChIKey : JGWRKYUXBBNENE-UHFFFAOYSA-N;

CAS number : 1029044-16-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1029044-16-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PLX3397; CML-261;

Codes from synonyms : 25485;

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14/05/2024


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