" /> Pexidartinib Hydrochloride - CISMeF





Preferred Label : Pexidartinib Hydrochloride;

NCIt synonyms : Pexidartinib Monohydrochloride; 5[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3yl]methyl}pyridin-2-amine Monohydrochloride; (5-(5-Chloro-1H-pyrrolo(2,3-b)pyridin-3-ylmethyl)-pyridin-2-yl)-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine Hydrochloride Salt; PLX3397 Hydrochloride;

NCIt definition : The hydrochloride salt form of pexidartinib, a small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.;

UNII : YS6WAI3XN7;

InChIKey : CJLUYLRKLUYCEK-UHFFFAOYSA-N;

CAS number : 2040295-03-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2040295-03-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Turalio;

Molecule name : FP-113;

NCI Metathesaurus CUI : CL1382556;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
14/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.