" /> Semaxanib - CISMeF





Preferred Label : Semaxanib;

NCIt synonyms : Semoxind; H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-;

NCIt related terms : SU5416; SU 5416;

NCIt definition : A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.;

Alternative definition : NCI-GLOSS: A substance that has been studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and tyrosine kinase inhibitors.;

UNII : 71IA9S35AJ;

InChIKey : WUWDLXZGHZSWQZ-WQLSENKSSA-N;

CAS number : 194413-58-6;

Molecule name : Sugen 5416; SU5416;

Chemical formula : C15H14N2O;

NSC code : 696819;

Codes from synonyms : CDR0000046162; CDR0000299584; 31699;

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31/07/2025


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