NCIt definition : A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly
inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth
factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration
and proliferation and reduce the tumor microvasculature. This agent also inhibits
the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often
expressed in acute myelogenous leukemia cells.;
Alternative definition : NCI-GLOSS: A substance that has been studied in the treatment of cancer. It belongs
to the families of drugs called angiogenesis inhibitors and tyrosine kinase inhibitors.;
UNII : 71IA9S35AJ;
InChIKey : WUWDLXZGHZSWQZ-WQLSENKSSA-N;
CAS number : 194413-58-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 194413-58-6
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G-SRS /a ;
Molecule name : Sugen 5416; SU5416;
Chemical formula : C15H14N2O;
NSC code : 696819;
Codes from synonyms : CDR0000046162; CDR0000299584; 31699;