Preferred Label : KIT-mutant Inhibitor DCC-3009;
NCIt synonyms : Pan-exon Mutant KIT Inhibitor DCC-3009; c-KIT Inhibitor DCC-3009;
NCIt definition : An orally bioavailable switch-control inhibitor of multiple mutated forms of mast/stem
cell factor receptor KIT (c-Kit; SCFR), with potential antineoplastic activity. Upon
oral administration, KIT-mutant inhibitor DCC-3009 targets and binds to the switch
pocket of c-Kit, thereby inhibiting the activity of specific c-Kit mutants, including
primary KIT mutations in exons 9 and 11 and secondary drug-resistant mutations across
exons 13, 14, 17, and 18. This may inhibit tumor cell proliferation in cancer cell
types that overexpress these c-Kit mutations. c-Kit, a transmembrane protein and receptor
tyrosine kinase (RTK) overexpressed in various solid tumors and hematological malignancies,
plays a key role in the regulation of cell differentiation and proliferation. Mutant
forms of c-Kit are often associated with tumor chemoresistance.;
Molecule name : DCC-3009; DCC 3009;
Origin ID : C212078;
concept_is_in_subset
- has_target
