" /> KIT-mutant Inhibitor IDRX-42 - CISMeF





Preferred Label : KIT-mutant Inhibitor IDRX-42;

NCIt synonyms : c-KIT Inhibitor IDRX-42; Multi-mutant-selective KIT Inhibitor IDRX-42; KIT Inhibitor IDRX-42;

NCIt related terms : IDRX-42;

NCIt definition : An orally bioavailable small molecule inhibitor of multiple mutated forms of mast/stem cell factor receptor KIT (c-Kit; SCFR), with potential antineoplastic activity. Upon oral administration, KIT-mutant inhibitor IDRX-42 targets, binds to and inhibits specific c-Kit mutants. This may inhibit tumor cell proliferation in cancer cell types that overexpress these c-Kit mutations. c-Kit, a transmembrane protein and receptor tyrosine kinase (RTK) overexpressed in various solid tumors and hematological malignancies, plays a key role in the regulation of cell differentiation and proliferation. Mutant forms of c-Kit are often associated with tumor chemoresistance.;

UNII : Y6UHU32G5Z;

CAS number : 2590556-80-0;

Molecule name : IDRX 42; IDRX-42; M-4205; M 4205;

NCI Metathesaurus CUI : CL1798791;

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12/05/2025


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