Ibcasertib - CISMeF

Preferred Label : Ibcasertib;

NCIt synonyms : Chiauranib;

NCIt definition : An orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. Upon oral administration, ibcasertib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. These kinases are overexpressed by a variety of cancer cell types.;

UNII : F40IRN5981;

CAS number : 1256349-48-0;

Molecule name : CS2164;

NCI Metathesaurus CUI : CL473304;

Details

Origin ID

C115970;

UMLS CUI

C3899686;

Currated CISMeF NLP mapping
- chiauranib [MeSH concept]
- chiauranib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- chiauranib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase B [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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