Preferred Label : Anti-c-Kit/MMAE Antibody-Drug Conjugate NN3201;
NCIt synonyms : Anti-CD117 ADC NN3201; Anti-CD117/MMAE Antibody-drug Conjugate NN3201; Anti-c-Kit Antibody-Drug Conjugate NN3201; Anti-c-Kit ADC NN3201; Anti-c-Kit/MMAE ADC NN3201; Anti-CD117 Antibody-drug Conjugate NN3201; Anti-CD117/MMAE ADC NN3201;
NCIt definition : An antibody-drug conjugate (ADC) composed of 2G4, a human monoclonal antibody directed
against the stem cell factor receptor c-Kit (SCFR; KIT; CD117), conjugated to the
auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl auristatin
E (MMAE), with potential antineoplastic activity. Upon administration of anti-c-Kit/MMAE
ADC NN3201, the 2G4 antibody targets and binds to the cell surface antigen c-Kit.
Upon binding and internalization, MMAE binds to tubulin and inhibits its polymerization,
which results in G2/M phase arrest and induces apoptosis in c-Kit-expressing tumor
cells. c-Kit, a transmembrane protein and receptor tyrosine kinase (RTK) overexpressed
in various solid tumors and hematological malignancies, plays a key role in the regulation
of cell differentiation and proliferation.;
Molecule name : NN-3201; NN 3201;
Origin ID : C213925;
concept_is_in_subset
- has_target
