Gastrointestinal Stromal Tumor

Preferred Label : Gastrointestinal Stromal Tumor;

NCIt synonyms : Gastrointestinal Stromal Neoplasm;

NCIt related terms : GIST, NOS; GISTs; Gastrointestinal Stromal Tumor (GIST); Gastrointestinal stromal tumor, NOS; GIST; Gastrointestinal stromal tumor, unspecified site;

NCIt definition : A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.;

Alternative definition : NCI-GLOSS: A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.;

Neoplastic status : Undetermined;

ICD-O code : 8936/1;

Codes from synonyms : 10051066; CDR0000044406; CDR0000044998; C49.A0;

Details

Origin ID

C3868;

UMLS CUI

C0238198;

Automatic exact mappings (from CISMeF team)
- Gastrointestinal stromal tumour, NOS [ICD-11 Extension code]
- Gastrointestinal stromal tumour, primary site [ICD-11 Category]
- Paraganglioma and gastric stromal sarcoma [OMIM Phenotype]
- intestinal cancer [MedlinePlus Topic]
Currated CISMeF NLP mapping
- Gastrointestinal stroma tumor [HPO term]
- Gastrointestinal stromal sarcoma [ICD-O code]
- Gastrointestinal stromal tumor [PASCAL descriptor]
- Gastrointestinal stromal tumor [OMIM Phenotype]
- Gastrointestinal stromal tumor [ORDO Disease]
- Gastrointestinal stromal tumor [MedDRA LLT]
- Gastrointestinal stromal tumor [HRDO Sign]
- Gastrointestinal stromal tumor (disorder) [SNOMED CT concept]
- Gastrointestinal stromal tumor, NOS [ICD-O code]
- Gastrointestinal stromal tumor, uncertain malignant potential (morphologic abnormality) [SNOMED CT concept]
- Gastrointestinal stromal tumour [ICD-11 Extension code]
- Gastrointestinal stromal tumour [MedDRA Preferred Term]
- gastrointestinal stromal tumor [DO Concept]
- gastrointestinal stromal tumor [Disease (Nov.)]
- gastrointestinal stromal tumor [Radlex concept]
- gastrointestinal stromal tumors [MeSH Descriptor]
- gastrointestinal stromal tumors [MeSH concept]
DO Cross reference
- gastrointestinal stromal tumor [DO Concept]
Disease excludes normal cell origin
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Gastrointestinal stroma tumor [HPO term]
- Gastrointestinal stromal sarcoma [ICD-O code]
- Gastrointestinal stromal tumor [OMIM Phenotype]
- Gastrointestinal stromal tumor [MedDRA LLT]
- Gastrointestinal stromal tumor (disorder) [SNOMED CT concept]
- Gastrointestinal stromal tumor (morphologic abnormality) [SNOMED CT concept]
- Gastrointestinal stromal tumour [MedDRA Preferred Term]
- gastrointestinal stromal tumor [Radlex concept]
- gastrointestinal stromal tumor [DO Concept]
- gastrointestinal stromal tumor [Disease (Nov.)]
- gastrointestinal stromal tumors [MeSH concept]
- gastrointestinal stromal tumors [MeSH Descriptor]
associated_with_malfunction_of_gene_product
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Portfolio Management Subtype Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Non-Rhabdomyosarcoma Soft Tissue Sarcoma Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- mCode Cancer Disorder Value Set [NCIt concept]
- mCode Elixhauser Malignant Solid Tumors without Metastases Value Set [NCIt concept]
- mCode Primary Cancer Disorder Value Set [NCIt concept]
- mCode Primary Malignant Neoplasm Disorder Value Set [NCIt concept]
- mCode Terminology [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Stromal Cell [NCIt concept]
disease_has_associated_disease
- Carney-Stratakis Syndrome [NCIt concept]
- Hereditary Gastrointestinal Stromal Tumor [NCIt concept]
disease_has_associated_gene
- Oncogene KIT [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Interstitial Cell of Cajal [NCIt concept]
- Stromal Cell [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_mapped_to_gene
- KIT Gene [NCIt concept]
- PDGFRA Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 14 [NCIt concept]
- Loss of Chromosome 1p [NCIt concept]
- Loss of Chromosome 22 [NCIt concept]
disease_may_have_molecular_abnormality
- KIT Gene Mutation [NCIt concept]
- PDGFRA Gene Mutation [NCIt concept]
may_be_associated_disease_of_disease
- Succinate Dehydrogenase-Deficient Tumor Syndrome [NCIt concept]
neoplasm_has_special_category
- Solid Neoplasm [NCIt concept]
pathogenesis_of_disease_involves_gene
- KIT Gene [NCIt concept]
- KIT wt Allele [NCIt concept]
- PDGFRA Gene [NCIt concept]
- PDGFRA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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