NCIt synonyms : Anti-FLT3/Anti-CD3 Bispecific Antibody CLN-049; FLT3 x CD3 Bispecific T Cell Engager CLN-049; FLT3 x CD3 Bispecific Antibody CLN-049;
NCIt definition : A T-cell-engaging, humanized, Fc-silenced immunoglobulin G1 (IgG1)-based bispecific
antibody directed against both the tumor-associated antigen (TAA) FLT3 tyrosine kinase
receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2)
and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-FLT3/CD3 bispecific antibody CLN-049 binds to
both CD3 on cytotoxic T-lymphocytes (CTLs) and FLT3 found on FLT3-expressing tumor
cells. This activates and redirects CTLs to FLT3-expressing tumor cells, which results
in the CTL-mediated cell death of FLT3-expressing tumor cells. FLT3, a cytokine receptor
belonging to the class III tyrosine kinase receptors, is overexpressed or mutated
in most B-lineage and acute myeloid leukemias (AMLs).;
Semantic type(s)