" /> Autologous Anti-FLT3 CAR-T Cells HG-CT-1 - CISMeF





Preferred Label : Autologous Anti-FLT3 CAR-T Cells HG-CT-1;

NCIt synonyms : HEMO-CAR-T; Autologous Anti-FLT3 CAR T-cells HG-CT-1; Autologous Anti-FLT3 CAR T Cells HG-CT-1;

NCIt definition : A preparation of autologous T-lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-FLT3 CAR-T cells HG-CT-1 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs).;

Molecule name : HG-CT 1; HG-CT1;

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30/07/2025


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